Vanqua Bio將於2025阿茲海默及帕金森會議發表新研究

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[Subject]: Young Asian female with "Imada Mio-inspired" doll-like aesthetic (精緻洋娃娃臉). She has large round expressive eyes, a small V-line face, and rosy cheeks. Her expression is innocent, energetic, and slightly flirty. [Hair]: Messy morning hair (剛睡醒的凌亂感), long dark brown hair, slightly tousled, natural volume. [Outfit]: Wearing an oversized translucent white button-down shirt (男友風白襯衫), unbuttoned at the top to reveal collarbones, creating a "bottomless" look (下衣失蹤風格). [Style]: Japanese Gravure Photobook style (寫真集風格), Pure & Sexy vibe, bright high-key lighting, soft skin texture, Fujifilm PRO 400H color tone.
Create a very realistic, cinematic image of a woman, with 100% of her original facial features maintained from the provided image. Do not alter the face, focusing on realistic details of the facial structure, eyes, eyebrows, nose, mouth, and expression. The lower left corner of the image features the Facebook logo and the text Nomahtan Kung.
Makeup: sharp Asian-style eyebrows, sharp Cat Eye eyeliner, and gradient red lipstick
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Vanqua Bio將於AD/PD™ 2025國際會議上發表演講

2025年3月27日,芝加哥 — Vanqua Bio,一家臨床階段的生物製藥公司,宣布將於2025年阿爾茨海默病和帕金森病及相關神經疾病國際會議(AD/PD™)上發表演講,會議將於4月1日至5日在奧地利維也納舉行。

Vanqua Bio演講信息:
標題:VQ-101,一種小分子全osteric激活劑,顯示出在人體中強健且持久的靶向參與
會議日期和時間:4月4日(星期六)下午4:55 CEST
演講者:Dr. Philip Kremer(CHDR)

此次演講將詳細介紹VQ-101在健康志願者及帕金森病(PD)患者中的階段1臨床試驗的中期結果。試驗的階段1a部分包括隨機、雙盲、安慰劑對照的單次和多次劑量上升試驗。在階段1a中,VQ-101實現了強健的外周和中樞暴露,耐受性良好,並顯示出活細胞溶酶體GCase的激活持續超過75%。這超過了研究的靶向參與目標50%的激活,該目標是基於人類遺傳學以及Vanqua在患者衍生的多巴胺神經元中的前臨床研究,該研究顯示50%的GCase激活能顯著阻止不溶性α-突觸核蛋白的積累,這是PD的病理特徵。目前,針對有無GBA突變的PD患者的階段1b試驗正在進行中,預計將於今年晚些時候完成。

關於Vanqua Bio

Vanqua Bio成立於2019年,總部位於芝加哥,是一家致力於發現和開發具有潛力改變神經退行性和炎症性疾病患者生活的下一代藥物的生物製藥公司。我們的技術平台利用人類遺傳學和患者衍生的中樞神經系統細胞來識別、驗證和臨床轉化與溶酶體功能障礙或先天免疫系統異常激活相關的新型疾病途徑。我們最初的目標是將葡萄糖腺苷酶(GCase)作為帕金森病(PD)的潛在治療方案。其他項目則針對外周和中樞炎症性疾病中先天免疫系統的過度激活,包括腎臟、皮膚和神經退行性疾病。欲了解更多信息,請訪問www.vanquabio.com。

這篇文章展示了Vanqua Bio在治療帕金森病方面的最新進展,特別是其VQ-101藥物的臨床試驗結果。值得注意的是,該公司的研究不僅聚焦於藥物的有效性,還充分考慮了患者的遺傳背景,這在現今的生物醫藥研發中愈發重要。隨著對神經退行性疾病的理解加深,像Vanqua這樣的公司正在開創新的治療途徑,這不僅能為患者帶來希望,也可能改變未來的治療標準。

此外,這種針對GCase的研究進一步強調了基因與疾病之間的關聯,未來或許會出現更多基於個體遺傳特徵的個性化醫療方案。這不僅是對現有治療模式的挑戰,更是對未來醫療發展的一種啟示,讓我們期待在這個領域中更多的突破。

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