PulseSight Therapeutics 宣布其 A 輪融資的首次完成，以資助 PST-611 在乾性老年黃斑變性中的臨床發展
巴黎，2025年2月13日（GLOBE NEWSWIRE）—— PulseSight Therapeutics SAS，一家專注於眼科的生物技術公司，致力於開發具顛覆性的非病毒載體療法及微創給藥技術，今日宣布其 A 輪融資的首次完成，現有投資者 Pureos BioVentures 承諾提供新資金，以支持 PST-611 的第一期研究並為第二期臨床試驗的準備工作提供資助。
PST-611 是一種首創的非病毒載體療法，用於治療乾性年齡相關性黃斑變性（AMD）/地理性萎縮（GA），其表達人類轉鐵蛋白，這是一種強效的鐵調節劑。轉鐵蛋白能恢復正常的鐵穩態，已在臨床前模型中顯示出強大的有益效果，能減少氧化壓力和炎症，並保護視網膜色素上皮的完整性，有潛力防止視網膜退化和視力喪失。
AMD 是老年人中央視力喪失的主要原因，全球有 2 億人受影響。AMD 的發病機制複雜，涉及鐵穩態的失調，導致自由鐵的過剩，進而引發炎症、氧化壓力和細胞死亡。
PulseSight 已經在其創新的技術中展示了良好的安全性，以及在非感染性葡萄膜炎的先前臨床計劃中證實的生物活性。
計劃中的 PST-611-CT1 臨床試驗主要旨在確認 PST-611 給藥的良好安全性，預計將於 2025 年第二季度啟動，具體時間取決於監管機構的批准，結果預計在 2025 年底或 2026 年初公布。
A 輪融資仍然對新投資者開放，以提供資金支持 PST-611 第二期臨床試驗的準備和實施，以及 PulseSight 更廣泛的非病毒載體療法組合的開發，包括 PST-809，這是一種潛在的首創療法，用於濕性 AMD，包含編碼強效抗 VEGF 的雙基因質粒，以及 decorin，一種抗血管生成和抗纖維化的天然蛋白。濕性 AMD 是一種複雜的疾病，涉及多條病理途徑，導致進一步的視力喪失，市場上仍然存在著顯著的未滿足需求。
PulseSight 的董事會成員及 Pureos Bioventures 合夥人 Dominik Escher 表示：“Pureos 很高興能繼續支持 PulseSight，幫助其推進我們相信能為視力喪失患者帶來真正改變的治療方案。PST-611 是在 GA 這一在歐洲尚未有批准治療的失明疾病中開發的。PST-611 擁有全新的作用機制，有潛力阻止疾病的進展，這是一個真正的高未滿足醫療需求。PulseSight 擁有創新能力和專業知識，有潛力成為眼科非病毒基因療法領域的一家高價值公司。”
PulseSight Therapeutics 的首席執行官 Judith Greciet 表示：“我們很高興能獲得資金來推進我們的主導計劃 PST-611，我們相信這將成為乾性 AMD/GA 患者的一個主要新治療選擇。這筆融資使我們能夠實現確認我們藥物候選者安全性的目標，然後迅速進入第二期概念驗證研究，以展示轉鐵蛋白保護視網膜細胞和保持視力的能力。”
PulseSight Therapeutics 的董事會主席 Dirk Sauer 表示：“我祝賀 Judith 和團隊在 2024 年迅速推進 PST-611，並歡迎 Pureos BioVentures 繼續支持我們的主導候選者。對於非病毒方法仍然存在未解決的需求，這將釋放基因療法的全部潛力。我對 PulseSight 的方法及其療法背後的數據感到鼓舞，期待著其他投資者加入我們的聯盟，以進一步通過臨床研究驗證 PulseSight 的顛覆潛力。”
關於年齡相關性黃斑變性（AMD）
AMD 隨著年齡增長而發展，是一種導致中央視力逐漸、無痛喪失的疾病，對患者的日常生活造成重大負擔，影響他們閱讀、識別面孔和看見物體的能力，最終導致不可逆的中央視力喪失。乾性 AMD 是最常見的 AMD 形式，經過多個階段進展至晚期乾性 AMD，也稱為地理性萎縮（GA）。濕性 AMD 是較少見的晚期 AMD 類型，導致更快的視力喪失。任何階段的乾性 AMD 都可能轉變為濕性 AMD。在所有形式中，AMD 代表著對更有效和持久治療選擇的迫切需求，市場規模龐大且不斷增長，預計到 2031 年將達到 275 億美元。
關於 PulseSight Therapeutics
PulseSight 是一家臨床階段的生物技術公司，致力於開發具顛覆性的非病毒載體療法，並採用微創給藥技術，旨在保護和改善患有視網膜疾病的患者的視力，特別是針對年齡相關性黃斑變性（AMD），包括濕性 AMD 和因乾性 AMD 而引起的地理性萎縮（GA）。
PulseSight 的技術平台已在臨床上證實其安全性和持續活性，能將編碼治療蛋白的 DNA 質粒通過電轉染系統送入睫狀肌。睫狀肌細胞作為生物工廠，表達的治療蛋白能高效分佈到視網膜，為主要眼病提供安全且持久的治療。
在這篇報導中，我們可以看到 PulseSight Therapeutics 在眼科領域的創新努力，尤其是在乾性 AMD 的治療上。這不僅是對患者的福音，也顯示了生物技術公司在解決未滿足醫療需求方面的潛力。隨著對視網膜疾病的研究不斷深入，未來可能會出現更多具突破性的療法，這對於提高患者的生活質量至關重要。這也提醒我們，持續的資金支持和創新是推動醫療進步的關鍵因素。
以上文章由特價GPT API KEY所翻譯及撰寫。而圖片則由FLUX根據內容自動生成。
🎨 Nano Banana Pro 圖像生成器｜打幾句說話就出圖
想畫人像、產品圖、插畫？SSFuture 圖像生成器支援 Flux 同 Gemini Nano Banana Pro 改圖 / 合成， 打廣東話都得，仲可以沿用上一張圖繼續微調。
![Ultra-realistic high-fashion studio portrait of a woman [image uploaded], vertical composition, framed from mid-chest to top of head. Camera at eye level, straight-on angle with a very slight head tilt to the subject’s left. Posture & pose: upright posture, shoulders relaxed. Left shoulder slightly forward, creating a gentle diagonal line across the collarbones. Arms relaxed out of frame, fur wrap resting naturally over the shoulders. Expression: calm, elegant, and composed. Soft neutral gaze directly into the camera, slightly parted lips with a subtle natural gloss. No smile, refined and confident mood. Face & skin: smooth fair skin with realistic texture and pores, soft luminous finish (not plastic or airbrushed). Rosy blush concentrated on the apples of the cheeks. Natural highlight on nose bridge, cheekbones, and collarbones. Eyes & makeup: large almond-shaped eyes, cool gray-brown irises. Long curled lashes, soft eyeliner, muted rose eyeshadow blended outward. Straight natural brows with gentle arch. Hair: short black bob cut just above the shoulders, slightly wavy ends. Center part with soft wispy strands framing the face. Large black satin bow tied at the back of the head, visible above the crown. Accessories: silver floral drop earrings with dangling details. Matching silver statement necklace with a central floral pendant resting at the upper chest. Clothing & styling: beige satin slip dress with thin spaghetti straps, smooth fabric with subtle sheen. Black faux-fur stole draped loosely around both shoulders, adding contrast and texture. Background: clean seamless light gray to off-white studio backdrop, evenly lit with no visible texture or distractions. Lighting: soft diffused beauty lighting from the front and slightly above eye level. Gentle fill light to reduce shadows, subtle rim light outlining hair and shoulders. Balanced highlights without overexposure. Color palette: neutral beige, black, silver, soft pink skin tones, minimal and elegant. Camera & settings: full-frame DSLR or mirrorless, 85mm lens, f/2–f/2.8, ISO 100, high sharpness on eyes, shallow depth of field. Image quality: ultra-high resolution, professional fashion photography, crisp details, natural skin realism. Strictly photorealistic human portrait — no illustration, no anime, no CGI, no digital painting, no doll-like skin.](https://ssfuture.shop/wp-content/uploads/ai_gen_1766038643-300x300.png)
![{
"intro": "Create an ultra realistic 8K UHD DSLR photo based on the attached image as a reference of facial features, maintaining 100% likeness.",
"subject": {
"identity": "A stylish beautiful woman portrayed as Cleopatra during her sacred milk bath beauty ritual, embodying divine femininity, sensual elegance, and timeless power.",
"angle": "Close-up beauty editorial captured at a refined 3/4 angle, focusing on her face, shoulders, and upper chest with extreme clarity and no blur.",
"pose": {
"body_position": "She is partially submerged in a luxurious milk bath, her shoulders and collarbones emerging gracefully from the surface.",
"hands": "One hand gently rests at the edge of the bath with milk droplets on her fingers, while the other lightly touches her neck adorned with subtle gold jewelry.",
"expression": "Soft yet commanding gaze directed toward the camera—calm, confident, intimate, and hypnotic."
}
},
"appearance": {
"outfit": "A barely-there, ritual-style ivory silk drape partially submerged in the milk bath, clinging softly to her skin. The fabric is delicate and translucent, edged with fine gold-thread embroidery for a sensual, sacred aesthetic.",
"accessories": "Minimal ritual jewelry—thin gold collar necklace resting above the milk surface, delicate arm cuff, subtle finger ring—kept refined to maintain focus on beauty and skin.",
"hair": "Her hair is sleek and ritual-polished, partially damp and slicked back at the crown, with soft wet strands framing her face naturally, reflecting candlelight.",
"makeup": "High-fashion Cleopatra beauty makeup with ceremonial artistry—perfectly sculpted brows, elongated black kohl eyeliner, vibrant eyeshadow layered in turquoise, teal, emerald, sapphire blue, and metallic gold. Beneath the eyes, subtle artistic ink-inspired accents echo ancient Egyptian symbolism. Her skin is luminous and dewy, cheeks softly flushed, and lips finished in a nude-rose satin sheen."
},
"ritual_props": {
"bath": "A carved alabaster bathtub filled with warm milk infused with honey, almond oil, and lotus essence.",
"floating_elements": [
"Fresh lotus flowers",
"Soft white rose petals",
"Delicate gold flakes shimmering on the milk surface"
],
"beauty_products": [
"Small golden perfume vial with lotus and myrrh oil",
"Alabaster bowl of honey and milk mixture",
"Clay jar of mineral kohl and pigment powders"
]
},
"background": {
"macro_environment": "An intimate royal bathing chamber within Cleopatra’s palace, designed as a sacred beauty sanctuary.",
"midground_details": "Soft linen curtains, glowing oil lamps, tall candles, and subtle steam rising from the bath, creating a warm and sensual atmosphere.",
"micro_elements": "Milk ripples around her skin, floating petals touching her shoulders, tiny droplets of moisture on her collarbones, reflections of candle flames on gold jewelry, visible stone texture on the tub, and delicate fabric translucency—every detail sharply rendered with zero blur."
},
"lighting": {
"type": "Warm cinematic candlelight combined with soft ambient palace glow.",
"effect": "Golden highlights sculpt her face and skin while gentle shadows enhance depth, intimacy, and divine beauty."
},
"camera": {
"camera_type": "DSLR",
"resolution": "8K UHD",
"lens": "85mm prime lens for beauty editorial compression",
"aperture": "f/8 for maximum facial and detail sharpness",
"iso": 100,
"shutter_speed": "1/160s",
"focus": "Extreme sharp focus on facial features, skin texture, makeup details, and milk surface, no bokeh, no blur"
},
"style": "Luxury beauty editorial, sacred milk bath ritual, ancient Egyptian goddess realism, intimate yet powerful, ultra-detailed, luminous skin focus, cinematic elegance"
}](https://ssfuture.shop/wp-content/uploads/ai_gen_1766006026-300x167.png)
![[Subject]: Young Asian female with "Imada Mio-inspired" doll-like aesthetic (精緻洋娃娃臉). She has large round expressive eyes, a small V-line face, and rosy cheeks. Her expression is innocent, energetic, and slightly flirty. [Hair]: Messy morning hair (剛睡醒的凌亂感), long dark brown hair, slightly tousled, natural volume. [Outfit]: Wearing an oversized translucent white button-down shirt (男友風白襯衫), unbuttoned at the top to reveal collarbones, creating a "bottomless" look (下衣失蹤風格). [Style]: Japanese Gravure Photobook style (寫真集風格), Pure & Sexy vibe, bright high-key lighting, soft skin texture, Fujifilm PRO 400H color tone.](https://ssfuture.shop/wp-content/uploads/ai_gen_1764973286-300x300.png)
