在Novo Nordisk贏得Ozempic擴展標籤以包含慢性腎病益處之際，Spherix Global Insights強調腎科醫生在GLP-1 RA使用中的日益影響
來自Spherix Global Insights的最新研究顯示，隨著慢性腎病（CKD）管理的演變，美國腎科醫生對GLP-1受體激動劑（GLP-1 RA）的採用率急劇上升。這一變化預計會在FDA最近擴展Novo Nordisk的Ozempic®標籤以包括CKD益處後加速，強化該藥物在腎臟護理中的日益重要性。
這項分析涵蓋了超過1,000份非透析CKD患者的病歷，顯示在這一人群中，GLP-1 RA的治療率從2023年到2024年幾乎翻倍。傳統上，GLP-1受體激動劑主要由內分泌科醫生和初級護理醫生開處方，但現在腎科醫生也越來越多地開始使用這些藥物，這反映出他們對這些藥物在血糖控制以外的益處（如減重和腎臟保護）的更廣泛認識。隨著Ozempic現在獲得FDA批准可用於糖尿病腎病（DKD）患者，預計採用率將繼續上升，大多數新開處方預計將發生在CKD第3期（eGFR約39 mL/min）的患者中。
同時，SGLT2抑制劑仍然是CKD治療的基石，在DKD患者中廣泛使用，並在非糖尿病CKD人群中逐漸增加。儘管DKD的使用已在經歷幾年的增長後達到高峰，但自2021年以來，非DKD的使用幾乎翻倍，這主要得益於AstraZeneca的Farxiga®和Eli Lilly/Boehringer Ingelheim的Jardiance®等主要療法的適應症擴展，促進了競爭激烈的治療市場。儘管臨床支持強勁，但一些開處方醫生仍然保持謹慎，特別是在非DKD的情況下，因為對於其潛在益處的認知仍然存在疑慮，這突顯了進一步教育的必要性，以提高對SGLT2抑制劑在減緩CKD進展方面的認識。
最後，礦物皮質激素受體拮抗劑（MRA），包括Bayer的Kerendia®，在DKD患者中的使用自2021年以來已經翻倍，但在過去一年中保持穩定。Kerendia主要作為ACE抑制劑/ARB和SGLT2抑制劑的第三線療法，其使用仍然受到腎臟保護益處的驅動。然而，對於高鉀血症等安全問題的擔憂，以及對其臨床益處的猶豫，限制了更廣泛的採用。
這些不斷演變的趨勢預示著CKD管理的一個變革時代，SGLT2抑制劑、GLP-1受體激動劑和MRA在其中扮演著越來越重要的角色。儘管這些變化帶來了新的機會，但安全考量和知識差距仍然是優化護理的障礙。隨著治療市場的進步，醫生、支付者和製藥公司之間的合作將對確保CKD患者及時獲得最有效的療法至關重要。
對此的思考與評論
這項研究顯示了CKD治療領域的顯著變化，尤其是GLP-1 RA的日益普及，這不僅反映了醫療界對新療法的接受度，也顯示出腎科醫生在患者管理中的重要性。隨著Ozempic的批准，未來的治療模式可能會出現更大的變革，這也意味著患者將能夠獲得更全面的治療選擇。
然而，儘管有這些進展，仍需注意安全性問題和醫療專業人員的教育。特別是在非DKD患者中，對於新療法的接受度仍然受到過去經驗的影響，這要求醫療界不斷更新知識和技能，以應對不斷變化的治療需求。未來，如何平衡新療法的引入與安全考量，將是醫療界需要面對的挑戰。
以上文章由特價GPT API KEY所翻譯及撰寫。而圖片則由FLUX根據內容自動生成。
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![{
"intro": "Create an ultra realistic 8K UHD DSLR photo based on the attached image as a reference of facial features, maintaining 100% likeness.",
"subject": {
"identity": "A stylish beautiful woman portrayed as Cleopatra during her sacred milk bath beauty ritual, embodying divine femininity, sensual elegance, and timeless power.",
"angle": "Close-up beauty editorial captured at a refined 3/4 angle, focusing on her face, shoulders, and upper chest with extreme clarity and no blur.",
"pose": {
"body_position": "She is partially submerged in a luxurious milk bath, her shoulders and collarbones emerging gracefully from the surface.",
"hands": "One hand gently rests at the edge of the bath with milk droplets on her fingers, while the other lightly touches her neck adorned with subtle gold jewelry.",
"expression": "Soft yet commanding gaze directed toward the camera—calm, confident, intimate, and hypnotic."
}
},
"appearance": {
"outfit": "A barely-there, ritual-style ivory silk drape partially submerged in the milk bath, clinging softly to her skin. The fabric is delicate and translucent, edged with fine gold-thread embroidery for a sensual, sacred aesthetic.",
"accessories": "Minimal ritual jewelry—thin gold collar necklace resting above the milk surface, delicate arm cuff, subtle finger ring—kept refined to maintain focus on beauty and skin.",
"hair": "Her hair is sleek and ritual-polished, partially damp and slicked back at the crown, with soft wet strands framing her face naturally, reflecting candlelight.",
"makeup": "High-fashion Cleopatra beauty makeup with ceremonial artistry—perfectly sculpted brows, elongated black kohl eyeliner, vibrant eyeshadow layered in turquoise, teal, emerald, sapphire blue, and metallic gold. Beneath the eyes, subtle artistic ink-inspired accents echo ancient Egyptian symbolism. Her skin is luminous and dewy, cheeks softly flushed, and lips finished in a nude-rose satin sheen."
},
"ritual_props": {
"bath": "A carved alabaster bathtub filled with warm milk infused with honey, almond oil, and lotus essence.",
"floating_elements": [
"Fresh lotus flowers",
"Soft white rose petals",
"Delicate gold flakes shimmering on the milk surface"
],
"beauty_products": [
"Small golden perfume vial with lotus and myrrh oil",
"Alabaster bowl of honey and milk mixture",
"Clay jar of mineral kohl and pigment powders"
]
},
"background": {
"macro_environment": "An intimate royal bathing chamber within Cleopatra’s palace, designed as a sacred beauty sanctuary.",
"midground_details": "Soft linen curtains, glowing oil lamps, tall candles, and subtle steam rising from the bath, creating a warm and sensual atmosphere.",
"micro_elements": "Milk ripples around her skin, floating petals touching her shoulders, tiny droplets of moisture on her collarbones, reflections of candle flames on gold jewelry, visible stone texture on the tub, and delicate fabric translucency—every detail sharply rendered with zero blur."
},
"lighting": {
"type": "Warm cinematic candlelight combined with soft ambient palace glow.",
"effect": "Golden highlights sculpt her face and skin while gentle shadows enhance depth, intimacy, and divine beauty."
},
"camera": {
"camera_type": "DSLR",
"resolution": "8K UHD",
"lens": "85mm prime lens for beauty editorial compression",
"aperture": "f/8 for maximum facial and detail sharpness",
"iso": 100,
"shutter_speed": "1/160s",
"focus": "Extreme sharp focus on facial features, skin texture, makeup details, and milk surface, no bokeh, no blur"
},
"style": "Luxury beauty editorial, sacred milk bath ritual, ancient Egyptian goddess realism, intimate yet powerful, ultra-detailed, luminous skin focus, cinematic elegance"
}](https://ssfuture.shop/wp-content/uploads/ai_gen_1766006026-300x167.png)
