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Arrowhead股價飆升 肥胖藥物臨床數據顯示體重減少翻倍
Arrowhead Pharmaceuticals（納斯達克代號：ARWR）股價近日急升16%，源於公司公布其基於RNA干擾技術的肥胖治療藥物，於肥胖兼患糖尿病患者身上展現出顯著的體重減輕效果。
公司報告指出，其實驗性藥物ARO-INHBE與tirzepatide聯合使用，在第16週達致平均9.4%的體重減少，約為單用tirzepatide時4.8%減重的兩倍。該組合療法在脂肪減少方面亦展現約三倍的提升，遠超tirzepatide單藥治療。
ARO-INHBE聯合tirzepatide使用時，內臟脂肪減少23.2%、總脂肪減少15.4%、肝臟脂肪更減少高達76.7%。作為單藥療法，ARO-INHBE於第16週單劑量使用時平均減少內臟脂肪9.9%，第24週雙劑量使用時，較安慰劑調整後減少達15.6%。
此外，Arrowhead亦公布另一RNA干擾療法ARO-ALK7的數據，該療法為首個在人類身上證實可抑制脂肪細胞相關基因表達的RNAi藥物。ARO-ALK7平均可降低88%的ALK7 mRNA，最高減幅達94%。單藥使用時於第8週單劑量後，較安慰劑調整的內臟脂肪減少率達14.1%。
都柏林大學醫學院化學病理及代謝醫學教授Carel le Roux博士表示：「Arrowhead公布的ARO-INHBE及ARO-ALK7臨床中期結果，顯示在內臟脂肪快速且顯著的減少，這是代謝疾病的主要致病因素。」
至今兩款療法均普遍耐受良好，大多數不良反應均為輕微。相關的第一/二期臨床試驗仍在進行中，預計2026年稍後會有更多結果公布。
—
編輯評論：
Arrowhead這次的臨床試驗數據，尤其是ARO-INHBE與tirzepatide的聯合療法，展現出翻倍的體重減輕效果，無疑為抗肥胖及糖尿病治療領域帶來嶄新的希望。內臟脂肪的顯著減少尤其重要，因為它與心血管疾病及代謝綜合症的風險息息相關。相比現有的肥胖藥物，這種RNA干擾技術能精準針對脂肪細胞基因，似乎開創了更有效且專一的治療方向。
然而，作為新型療法，安全性和長期效果仍需時間檢驗。早期數據雖令人振奮，但後續臨床試驗的規模擴大及更長期的觀察結果，才可真正確定療效及風險平衡。此外，這種療法的成本及普及性亦是實際應用的關鍵挑戰。
對投資者而言，Arrowhead股價的急升反映市場對其技術潛力的高度期待，但同時也意味著風險與波動性。持續關注臨床數據更新及監管進展，對判斷其未來走勢至關重要。
總括來說，Arrowhead的RNAi療法為肥胖及糖尿病治療帶來突破，值得醫療界和投資界繼續追蹤。這種精準且多重作用機制的策略，有望在未來成為改變肥胖治療格局的新標杆。
以上文章由GPT 所翻譯及撰寫。
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![Ultra-detailed pastel kawaii cosplay portrait of a woman [image uploaded] character, posed with hands gently pressed together under her chin in a soft, doll-like gesture; vivid long wavy hair in split-gradient lavender and pink with styled curled ends; straight bangs dyed pastel lavender; decorative accessories throughout the hair including pastel bows, lace ribbons, small charms, and a frilled white lace headpiece with pink accents; makeup: heavy kawaii style with saturated pink eyeshadow, pink blush extending across cheeks and nose, glossy pink lips, heart-shaped cheek stickers, and large contact-lens-enhanced eyes; outfit: pastel pink lace wrist cuffs with big bows and heart embellishments, soft pastel clothing with ribbons and frills; background: dreamy soft-focus bokeh in shimmering pink tones creating a magical fairytale atmosphere; lighting: bright soft diffused beauty lighting with zero harsh shadows, high exposure pastel glow, smooth porcelain skin texture, ultra-saturated colors, whimsical fantasy aesthetic, high-resolution portrait photography. Negative: no real-person likeness, no watermark, no text, no distortion, no extra limbs, no deformed face, no realism unless stylized, no background objects.](https://ssfuture.shop/wp-content/uploads/ai_gen_1765323126-300x201.png)
![{
"image_generation_request": {
"prompt": "Ultra-realistic portrait of a man walking toward the camera on an airport runway at night He wears a white long-sleeve shirt with sleeves rolled up and dress pants, shoes. The camera is very close, capturing his face sharply - textures of skin, smoke from his lips, and subtle reflections of firelight in his eyes. Behind him, slightly out of focus, a commercial airplane is burning intensely, with huge flames, roaring firestorms, and thick black smoke rising high. The fiery glow casts dramatic orange highlights on his shirt and face, creating deep shadows and a gritty, cinematic mood. Wet runway reflects the blaze, enhancing the dramatic atmosphere.",
"dimensions": {
"width": 1200,
"height": 1200
},
"style_descriptors": [
"Cinematic",
"Photorealistic",
"Gritty",
"Dramatic Lighting",
"Macro Photography",
"8k resolution"
],
"subject_details": {
"action": "Walking toward camera, smoking",
"clothing": "White long-sleeve shirt (rolled sleeves), dress pants, shoes",
"facial_features": "Sharp focus, skin texture, firelight reflection in eyes"
},
"environment_details": {
"location": "Airport runway at night",
"background": "Commercial airplane burning, intense fire, thick black smoke, out of focus",
"ground": "Wet runway, reflecting fire"
}
}
}](https://ssfuture.shop/wp-content/uploads/ai_gen_1765251172-300x300.png)
