AI 助力藥物研發,五間初創公司挑戰極限!

Ai




利用人工智能設計小分子藥物的挑戰:五家公司在努力破解這個難題

這些初創公司已經籌集了數億美元,並希望加速藥物發現的進程。

健康科技記者Brittany Trang報導,Ian Quigley曾是AI藥物公司Recursion的第13名員工,直到2021年他辭職,並將自己位於猶他州的家地下室改造成實驗室,專注於開發AI模型,以預測小分子藥物可能靶向的蛋白質。他和聯合創始人Andrew Blevins在Recursion工作期間發現,這樣的工具是缺失的。

在設置實驗室時,Quigley訂購了一台Illumina DNA測序儀,送貨員本來想把它放在他家的門廊上。出於對這個主意的恐懼,他決定開著自己的Toyota Yaris去取貨,並將後座放倒,把儀器放在狗的犬舍旁邊。

在這個地下室實驗室裡,Quigley和他的Leash Bio小組產生了約1.33億個小分子與蛋白質靶點結合的數據點。今年早些時候,他們將這些數據作為培訓材料,參加一個比賽,旨在確定任何AI模型在預測小分子與蛋白質互動時是否真正學習了生物學知識,還是僅僅在記憶之前見過的內容。

這篇文章深入探討了AI在藥物開發中的應用,特別是小分子藥物的發現過程。Quigley的故事不僅展示了創新精神,也反映了目前生物技術行業中對於AI技術的需求和挑戰。隨著AI在藥物發現中的應用越來越普遍,如何確保這些技術能夠真正理解生物學而非僅僅進行數據記憶,將成為未來研究的重要課題。

值得注意的是,這些初創公司在面對的挑戰不僅是技術上的,還包括如何將這些創新轉化為實際的藥物,並在競爭激烈的市場中脫穎而出。隨著資金的注入和技術的進步,未來的藥物開發可能會出現革命性的變化,但這需要業界的共同努力和持續的創新。

以上文章由特價GPT API KEY所翻譯及撰寫。而圖片則由FLUX根據內容自動生成。

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Base Setup
keep 100 percent facial information adherence of the attached image and turn her into a lone traveler posed on a sunlit desert dune ridge, captured as a live action photograph or movie still, not an illustration or CGI render, with a sexy, confident, heat soaked editorial mood.

Shot and Camera
Full body shot from slightly low height, framing her on the right third, with sweeping dunes rolling into the distance on the left, using a wide cinematic lens feel that keeps the landscape vast and minimal.

Identity and Pose
She has a slim, toned build, medium height impression, sun kissed skin, and long loose hair blown by the wind. She stands barefoot on the crest, one leg forward so the hip shifts naturally, one hand resting on her upper thigh and the other lightly gripping a sheer wrap at her side, wearing a high cut desert bikini with a gauzy open sarong that shows plenty of leg and midriff without nudity, head turned over her shoulder with a subtle, knowing smile, 8k Photorealistic and hyper realistic.

Lighting and Environment
Harsh midday sun from high right casts crisp shadows along her body and the dune ripples, with soft sky bounce filling the shadows enough to keep detail. The sand textures, wind carved ridges, and pale blue sky remain exactly like the reference, with faint footprints and slight imperfections grounding her on the slope.

Masking and Constraints
Change only by adding the subject and her wardrobe, keep dune shapes, lighting direction, perspective, horizon line, and white balance identical, preserving realistic body proportions and clear contact between her feet and the sand. Absolutely no added text, no painterly or toon look, no CGI plastic skin, no see through fabric on intimate areas, no warped limbs or floating feet, strictly require consistent perspective, natural film like grain, fine skin texture and sand detail, and physically correct contact shadows in the sand depressions around her feet. Base Setup
keep 100 percent facial information adherence of the attached image and turn her into a girl standing beneath autumn leaves outside a traditional wooden structure in a live action photograph or movie still, wearing a complex suggestive outfit that harmonizes with the warm fall tones.

Shot and Camera
Three quarter shot at slightly low height, framing her off center to the right so the yellow leaves and carved wooden panels dominate the left. Maintain the intimate close framing and vertical orientation feel of the reference.

Identity and Pose
Preserve her age read, build, silhouette, hairstyle length, and skin tone. She leans lightly against the doorframe, one hand grazing a hanging leaf, her posture relaxed and candid, 8k Photorealistic and hyper realistic.

Lighting and Environment
Soft warm daylight filters through the leaves, casting dappled highlights on her hair and outfit. Ground her feet on aged wooden flooring with natural grain, faint scuffs, and subtle contact shadows.

Masking and Constraints
Change only wardrobe and placement while keeping lighting, perspective, white balance, pose, face geometry, body proportions, and silhouette the same. Absolutely no added text, no CGI look, no plastic skin, no floating feet, with consistent perspective and correct contact shadows. Prompt:
Use my image in Ultra-realistic, hyper-detailed, 8K cinematic portrait of a young stylish man, using the uploaded image for exact face and hairstyle.
Outfit: An oversized red knit sweater with white hearts, exactly as described in the prompt.
Pose: A hyper-realistic close-up portrait with a messy, cropped framing showing only the boy holding the book. His left hand rests on the wooden table and covers part of his cheek, with a subtle smile on his lips. His other hand holds the book titled "Something I Never Told You" with the word "YOU" written in pink, exactly as
described in the prompt. Background: Not specified.