諾華斥14億美元收購Tourmaline生物醫藥公司




諾華斥資14億美元收購Tourmaline Bio

瑞士製藥巨頭諾華(Novartis)於週二宣佈,將以每股48美元的價格收購總部位於紐約的生物製藥公司Tourmaline Bio,整體估值達14億美元(按完全稀釋計算)。

Tourmaline Bio專注於研發針對動脈粥樣硬化性心血管疾病的創新療法pacibekitug,該藥物有望有效減少全身性炎症反應,成為該疾病的治療新選擇。諾華表示,此次收購將為其現有的心血管疾病產品組合增添一項已進入第三期臨床試驗階段的資產。

雙方董事會均已一致通過該交易,諾華將啟動公開收購行動,買下Tourmaline Bio所有流通在外的普通股。該交易預計於今年第四季度完成,屆時Tourmaline Bio將成為諾華的間接全資子公司。

評論與分析:

諾華此次以14億美元收購Tourmaline Bio,展現了其在心血管疾病領域加強研發和產品佈局的決心。動脈粥樣硬化是全球範圍內主要的心血管疾病成因之一,對於減少全身性炎症的療法需求殷切。Pacibekitug作為一款具備潛力的靶向治療藥物,若能成功上市,將為患者帶來新的治療選擇,亦有助於諾華在激烈的市場競爭中鞏固領先地位。

此外,此次收購反映出大型製藥企業對生物製藥初創公司的高度關注,尤其是那些擁有有望進入臨床後期的創新藥物的公司。諾華透過此舉不僅能快速擴充產品線,還能借助Tourmaline Bio的研發成果,縮短新藥上市時間,提升競爭力。

不過,值得留意的是,第三期臨床試驗雖是新藥上市前的重要關卡,但仍存在不少不確定性,包括療效、安全性及監管審批風險。諾華如何整合Tourmaline Bio的技術與資源,並推動pacibekitug順利通過審批,將是未來成敗的關鍵。

總括而言,這宗收購案是製藥行業持續創新與整合趨勢的縮影,亦突顯了大企業對於心血管疾病治療市場潛力的重視。對香港及亞洲市場而言,這類國際大型藥企動作,將帶來更多前沿治療技術的引入與合作機會,值得業界持續關注。

以上文章由特價GPT API KEY所翻譯及撰寫。

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Three quarter body shot from slightly low height on the riverbank, placing her on the left third while the water leads into the dark canyon and the star filled sky dominates the top of the frame, preserving the original wide vertical composition.

Identity and Pose
She has a slim athletic build, natural proportions, medium length loose hair, and lightly tanned skin, 8k Photorealistic and hyper realistic. She stands barefoot in the water with one leg forward, hips relaxed, wearing a fitted cropped technical top and separate high waisted trail shorts with an open lightweight jacket slipping off one shoulder, one hand loosely holding a headlamp at her side and the other brushing hair from her face as she looks up at the stars.

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Keep the soft starlight and faint glow from the distant horizon, giving a gentle rim on her shoulders and hair while a subtle fill from the reflected sky reveals her features. The canyon walls, river reflections, pebbled shore, and dense star field stay exactly like the reference, with small ripples around her feet grounding her in the water.

Masking and Constraints
Change only by adding the subject and her outfit, keep lighting, perspective, white balance, canyon geometry, and river reflections the same, with realistic scale, body proportions, and clear contact between feet and water surface. Change only the requested element and keep lighting, perspective, white balance, pose, face geometry, body proportions, and silhouette the same, and absolutely avoid added text, painterly or toon styling, CGI look, blown highlights, banding, plastic skin, overly tidy backgrounds, or floating feet while requiring consistent perspective, consistent white balance, subtle film like grain, and physically correct contact shadows and reflections. {
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"subject": {
"identity": "A stylish beautiful woman portrayed as Cleopatra, the eternal Queen of Egypt, exuding power, seduction, and divine authority.",
"angle": "Full-body editorial portrait captured at a refined 3/4 angle, with both the subject and her throne positioned diagonally, rendered in ultra-crisp clarity with no blur.",
"pose": {
"body_position": "She is seated regally on a luxurious Egyptian throne angled slightly to the side, her torso and legs elegantly turned to match the diagonal composition, enhancing her curves and royal poise.",
"hands": "One arm rests gracefully along the angled armrest of the throne, while the other cradles a magnificent royal cat against her body.",
"expression": "She looks directly into the camera with a composed, intelligent, and seductive gaze—calm authority mixed with magnetic allure."
}
},

"appearance": {
"outfit": "An exceptionally bongga, sexy, and ultra-colorful Cleopatra couture gown designed as a high-fashion masterpiece. The gown features a sculpted corset bodice encrusted with multicolored gemstones—turquoise, lapis blue, emerald green, ruby red, amethyst violet, and molten gold—arranged in intricate Egyptian patterns. The fabric transitions into layered sheer silks in jewel tones that cascade dramatically, creating movement and depth. A daring thigh-high slit reveals her leg, while illusion panels and crystal embroidery contour her waist and hips. The gown shimmers with every hue, bold yet luxurious, sensual yet undeniably royal.",
"accessories": "A dramatic Egyptian crown with raised cobra centerpiece and iridescent gemstone inlays, oversized multi-layered gold collar necklace, engraved arm cuffs, crystal-encrusted finger rings, an ornate gold waist belt, anklets with delicate charms, and elegant flat Egyptian sandals.",
"hair": "Her hair is shoulder-length, sleek, and glossy with soft movement, modernized yet inspired by ancient Egyptian elegance, no bangs.",
"makeup": "High-impact, colorful Egyptian glam makeup—intensely elongated kohl eyeliner, bold eyeshadow blended in gold, turquoise, teal, emerald, and hints of violet, sculpted cheekbones with luminous gold highlight, flawless bronzed skin, defined brows, and rich nude-to-berry satin lips with a sensual glow."
},

"props": {
"animal": "A stunning, regal Egyptian cat of exceptional beauty, with sleek, glossy fur patterned in warm sand, charcoal, and soft gold tones. The cat has large almond-shaped eyes that glow amber-gold, finely sculpted features, and an elegant posture. It wears a delicate gold collar adorned with tiny gemstones and a miniature Bastet charm, symbolizing protection, divinity, and royal favor."
},

"background": {
"macro_environment": "A grand royal palace courtyard in ancient Egypt at golden hour, composed diagonally to echo the angled throne, with towering sandstone columns, carved relief walls, and distant pyramids beneath a richly colored desert sky.",
"midground_details": "Palm trees gently swaying, monumental statues of Bastet and other Egyptian deities, ceremonial fire torches, flowing silk banners in jewel tones, and distant palace attendants positioned subtly for scale.",
"micro_elements": "Ultra-sharp hieroglyph carvings, visible stone grain and chisel marks, fine desert sand particles, radiant gemstone reflections, metallic gold highlights, intricate embroidery threads, and realistic sun-cast shadows—every element sharply defined with zero blur."
},

"lighting": {
"type": "Cinematic natural golden-hour lighting enhanced with soft reflective fill light.",
"effect": "Warm sunlight amplifies the vivid colors of the gown and gemstones while sculpted shadows define her face, body, throne, and the cat, creating a dramatic yet luxurious editorial mood."
},

"camera": {
"camera_type": "DSLR",
"resolution": "8K UHD",
"lens": "50mm prime lens",
"aperture": "f/8 for maximum sharpness across subject and background",
"iso": 100,
"shutter_speed": "1/200s",
"focus": "Extreme sharp focus from foreground to background, no bokeh, no blur"
},

"style": "High-fashion editorial, cinematic realism, ultra-luxury Egyptian couture, vibrant jewel-toned palette, historical grandeur fused with modern sensuality, extremely detailed, sharp, powerful, and seductive"
} A striking black-and-white cinematic photograph of a mysterious woman standing calm and composed in the center of a dense crowd of paparazzi, dozens of photographers surrounding her, all aiming vintage cameras with flashes raised. The woman wears dark sunglasses, minimal makeup, and an elegant dark outfit, her expression emotionless and powerful, symbolizing isolation amid fame. High contrast lighting, dramatic shadows, shallow depth of field, sharp focus on the central subject, blurred foreground faces and cameras, classic film grain, 35mm analog photography style, noir aesthetic, timeless Hollywood atmosphere, intense realism, editorial fashion photography, moody, iconic, award-winning composition.