腦癌加拿大撥款85萬研究突破性腫瘤治療




腦癌加拿大頒發85,000美元資助予尖端的復發性膠質母細胞瘤研究
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2025年5月26日 09:00 ET  | 來源: 腦癌加拿大

多倫多,2025年5月26日(GLOBE NEWSWIRE)——腦癌加拿大欣然宣布,將85,000美元的研究資助頒發給多倫多大學的斯蒂芬·安傑斯博士,支持其項目《發現復發性超突變膠質母細胞瘤中的藥物靶點》。這項創新研究旨在為膠質母細胞瘤(GBM)尋找新的治療策略,這是最難以治療的腦癌之一。

儘管標準的積極治療方法(包括手術、化療和放療)已經實施,但復發性GBM腫瘤幾乎無法避免地會出現。至今,針對復發性GBM的有效藥物靶點仍然缺乏。大約15%的復發性GBM腫瘤會在MSH6基因中獲得突變,這會導致對化療的抵抗,並引發一種稱為超突變的現象,特徵是累積了大量額外的突變。

安傑斯博士的實驗室初步發現,超突變的GBM細胞可能對已經獲批准用於其他臨床用途的抗葉酸藥物表現出更高的敏感性。該團隊的項目有兩個主要目標:首先,評估超突變和非超突變復發性GBM細胞之間的藥物敏感性差異;其次,利用尖端的基因篩查技術來識別這一特別難治腫瘤亞型的其他治療靶點。

通過這項工作,安傑斯博士及其團隊希望為開發更有效的靶向療法奠定基礎,這些療法可能顯著改善面對復發性GBM患者的治療效果。他解釋道:“我們發現腫瘤細胞中的潛在基因脆弱性,這可能意味著某些復發性膠質母細胞瘤的病例可以用市場上已經存在的藥物進行治療。慈善社區的慷慨和奉獻對我們這些生物醫學科學家在癌症研究方面的進展至關重要。我們對腦癌加拿大及其捐贈者和籌款者的支持深表感激。”

這項資助得益於來自全加拿大的草根倡議和紀念捐款,包括索特斯特瑪麗戰士、為腦癌做的俯臥撐活動,以及紀念伯納多·斯卡利西、羅克珊·坦頓和格雷格·麥克萊恩的籌款活動。

這一公告是腦癌意識月期間宣布的六項資助之一。腦癌加拿大致力於推動創新解決方案,並為受到腦癌影響的人們追求希望,通過投資急需的研究來實現這一目標。

關於腦癌加拿大
腦癌加拿大是一個全國性慈善機構,致力於改善受原發性惡性腦腫瘤影響的人的生活,通過資助研究、倡導有效的治療選擇以及投資神經外科技術。自2015年以來,腦癌加拿大已經向全國的九個機構、研究中心和醫院的25個項目提供了超過240萬美元的腦癌研究資助。

更多信息

如需了解有關腦癌加拿大支持的其他研究倡議的詳細信息,請訪問腦癌加拿大的官方網站。

這項研究資助的宣布不僅是對安傑斯博士及其團隊努力的肯定,也是對整個腦癌研究領域的一次重要推進。隨著對腦癌的認識不斷深入,尤其是針對復發性膠質母細胞瘤的治療需求日益迫切,這項研究的成果將可能為患者帶來新的希望。值得注意的是,這些研究不僅限於新藥的開發,也可能促使現有藥物的重新評估和應用,這對於資源有限的醫療系統來說,無疑是一個成本效益高的解決方案。希望未來能有更多類似的研究得到支持,為腦癌患者帶來更好的治療選擇和生活質量。

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