美國FDA批准CAH藥物 Neurocrine股票大漲

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Generate an ultra-realistic, highly ultra-detailed, 8k resolution with 1080x1080 pixel portrait of me using the uploaded image for reference (preserved the likeness and the original face for reference) of a cinematic studio portrait of a woman seated on a simple wooden chair with a minimalist design, positioned slightly to the left of the frame. She is captured in a contemplative pose, with her body turned to the left, her left arm resting gracefully on the back of the chair, and her right hand gently touching her face near her lips, conveying a sense of introspection and elegance. Her long, wavy hair cascades naturally over her shoulders, framing her face and adding softness to the composition. She wears an oversized, textured knit sweater that slips off her shoulders, exposing her collarbones and upper chest, emphasizing a relaxed and intimate mood. Her legs are bare, with her right foot flat on the ground and her left knee slightly raised, creating a dynamic line that guides the viewer’s eye through the composition. *** The background is a seamless, deep charcoal or dark brown studio backdrop, providing a rich, neutral setting that enhances the dramatic lighting. The lighting setup features a single, soft yet directional light source positioned to the left of the subject, casting gentle, sculptural shadows that highlight the contours of her face, shoulders, and arms, while creating a subtle gradient across her form. The light accentuates the texture of her sweater and the natural shine of her hair, adding depth and dimension to the image. The color palette is monochromatic with warm, muted tones—shades of gray, brown, and beige—contributing to a timeless, artistic aesthetic. The image is shot with a professional full-frame camera using an 85mm or 50mm lens at a wide aperture (f/1.8 to f/2.😎 to achieve a shallow depth of field, ensuring the subject is in sharp focus while the background remains softly blurred. The resolution is ultra-high, capturing every detail from the fine texture of her sweater to the subtle expression of her pose. The overall style is elegant, contemplative, and refined, emphasizing mood and atmosphere over overt glamour. Post-processing is minimal, maintaining natural skin tones, enhancing contrast and clarity, and preserving the authenticity of the scene. This portrait embodies a delicate balance between simplicity and emotional depth, making it suitable for fine art, editorial, or fashion photography.
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Create a photorealistic movie-poster image for Zootopia 2. The scene shows a young Asian man and an oversized black shirt standing inside a crowded, dimly lit cinema. He’s flanked by Judy Hopps in full police uniform and Nick Wilde, both rendered in their official Disney CGI style. Capture the shot from a low angle so the characters feel larger than life. The cinema screen behind them is glowing with an intense action scene from the film. Let the light from the screen spill across their faces and clothing to create dramatic high contrast. The environment should feel alive with background silhouettes, soft haze, and the warm ambience of a packed theatre. Style the composition like an official Disney promotional poster: epic layout, sharp detail, high resolution, balanced framing, and clean edges. The man and the cinema should be fully photorealistic, while Judy and Nick retain their signature animated look. At the bottom, include: • The Disney logo • The title ZOOTOPIA 2 in bold green and white • The release line ONLY IN THEATERS NOVEMBER 26 Poster tone: cinematic, polished, high-end theatrical marketing.
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Neurocrine Biosciences因FDA批准CAH藥物而股價上升

Neurocrine Biosciences, Inc.（NASDAQ:NBIX）的股價上升了5.7%，這得益於美國食品藥品監督管理局（FDA）對其新藥CRENESSITY的批准。CRENESSITY是一種治療先天性腎上腺增生（CAH）的新藥，這是第一種能夠直接針對並減少過量的腎上腺皮質促素（ACTH）和腎上腺雄激素產生的藥物，適用於這一遺傳疾病的患者。

FDA對CRENESSITY的批准，標誌著一項重要的進展，特別是對於受到經典型CAH影響的患者，這是一種罕見且終身的疾病，影響腎上腺功能。該藥物的批准於週五宣布，預計在一周內將通過專門藥房PANTHERx Rare正式上市。

Neurocrine Biosciences的首席執行官Kyle W. Gano博士強調了公司在CAH研究方面的長期承諾，並感謝臨床試驗的參與者和研究人員在推動這一新藥物進入CAH社區中的貢獻。CARES基金會的執行董事Dina Matos也表示，這種藥物有潛力改善CAH患者的生活質量，減少對高劑量類固醇治療的需求。

儘管FDA的批准反應積極，分析師預計商業推出將是漸進的。BMO Capital的Evan David Seigerman指出，廣泛的商業接入預期要到2025年下半年才能實現，而且該藥物的黑盒警告要求對類固醇療法調整進行仔細監控。

高盛的Chris Shibutani則認為這一批准是Neurocrine Biosciences的一個正面里程碑，確認了其在多個治療領域成功開發多種藥物的生物技術公司地位。該分析師提到，雖然初期的推出路徑可能難以量化，但公司在患者吸納和擴展可及性及保險覆蓋的進展將會受到密切關注。

這一消息不僅對Neurocrine Biosciences的股價產生了積極影響，更可能引發市場對於生物技術行業的進一步關注。隨著新藥物的推出，患者的需求和市場的反應將是未來監測的重點。這樣的發展不僅為CAH患者帶來了新的希望，也可能為生物製藥行業的其他公司樹立一個成功的範例，激勵他們在類似的疾病治療上進行更多的研究和開發。

以上文章由特價GPT API根據網上資料所翻譯及撰寫，過程中沒有任何人類參與 🙂

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Use the original face exactly as it is, without changing a details. A female model with sharp features, defined cheekbones, and intense, direct eye contact (though eyes are slightly in shadow from the hat). • Aesthetic: Vintage fashion, Pin-up, 1950s/1960s style, high-glamour, summer resort wear. • Lighting: Bright, harsh sunlight creating high contrast and crisp shadows. The light should perfectly illuminate the skin and the vibrant colors of the dress. • Color Palette: Dominated by vibrant yellow, crisp white, and bold red, accented by deep black. Specific Outfit & Details: • Dress: A bright yellow halter-neck sundress with a classic white polka-dot pattern. It has a fitted, sweetheart neckline or bustier-style top that enhances the silhouette. • Accessories: • A very large, wide-brimmed sun hat in crisp white (or light straw/fabric) that casts a shadow over the upper face. • A matching yellow polka-dot scarf tied closely around the neck (like an ascot or choker-style). • Large, striking black statement earrings (circular, drop, or bead style). • Bold red lipstick is a key feature, contrasting sharply with the yellow and white. Technical/Camera Details: • Shot: Close-up or medium-close-up portrait, focusing on the torso, neckline, face, and hat. • Depth of Field: Shallow (low f-stop), with the model in sharp focus and the background slightly blurred (bokeh). • Background: Out-of-focus, suggesting a bright outdoor location, with abstract shapes of boats/yachts (white and red accents visible) in a marina setting. Create a hyper-realistic cinematic scene inside a traditional Wing Chun training hall. The man from the uploaded reference image is training at a wooden dummy with Ip Man standing beside him, personally correcting his technique. Keep both faces accurate to the reference image: exact skin tone, hairstyle, age, expression, and natural sweat on their skin. Both wear classic black Wing Chun uniforms with white cuffs. Show Ip Man’s calm, focused guidance as he places his hands near the student’s arms on the wooden dummy. Capture the wooden dummy with polished texture and rich warm tones. Include authentic Chinese decor: calligraphy scrolls, carved wooden frames, soft lantern light, and other students blurred in the background. Use shallow depth of field, warm natural lighting from the windows, and crisp detail on clothing and skin. The scene should feel like a still frame from an Ip Man movie, grounded, disciplined, and cinematic. Use the original face exactly as it is, without changing a details. A stunning, very fit female model with a sun-kissed, glowing tan (hyper-realistic, high-sheen skin texture). • Attire: A strapless, high-waisted one-piece swimsuit (or very closely cut two-piece) in a dark navy or black color with prominent white polka dots. The suit has a cutout design around the midriff and a knotted/bow detail at the bust. • Accessories: • An oversized straw sun hat with a wide brim, featuring a colorful striped ribbon band. • Large, chunky yellow or gold hoop earrings with a woven/textured design. • Hair & Makeup: Classic glamour style. Bright, bold red lipstick. Hair is pulled back or tucked under the hat. Setting & Composition • Background: A solid, seamless, rich mustard yellow or deep ochre/orange-yellow color, providing a warm, high-contrast backdrop. • Prop: The model is leaning on an antique or elaborate wooden armchair or chaise lounge with ornate carvings and textured, light gold/yellow upholstery (e.g., damask or brocade). • Pose: Confident, classic, slightly leaning into the prop, looking directly at the camera with a bright, genuine smile. Three-quarter body shot. Style & Lighting • Lighting: Dramatic, high-key, professional studio lighting with a strong single light source to create deep shadows and extreme highlights, especially catching the sheen on the model's skin. The lighting emphasizes a sultry, glamorous mood. • Aesthetic: High-fashion editorial, Pin-up, Retro 1950s Glamour, Vintage Summer. • Keywords/Details: Hyper-detailed, photorealistic, cinematic lighting, rich texture, high contrast, high sheen.